Description

5(6)-Dehydro-4(5)-Dihydro D-(-)-Norgestrel is a key pharmaceutical intermediate and a structurally modified derivative of the progestin norgestrel. This compound is critical for the research and development of novel steroidal drugs and advanced hormonal therapies. It is primarily utilized by pharmaceutical R&D laboratories, API manufacturers, and academic institutions focused on endocrinology and synthetic organic chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of advanced steroidal active pharmaceutical ingredients (APIs).
• Progestin Research: Serves as a reference standard and starting material for the development of new progestin-based contraceptives and hormone replacement therapies.
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway studies related to norgestrel and its analogs.
• Chemical Reference Standard: Employed in analytical laboratories for method development, validation, and quality control testing of related steroid compounds.
• Academic & Industrial R&D: Fundamental material for investigating structure-activity relationships (SAR) in steroid chemistry and discovering new therapeutic agents.

Basic Information

Product Name	5(6)-Dehydro-4(5)-Dihydro D-(-)-Norgestrel
CAS No.	100021-05-4
Molecular Formula	C₂₁H₂₈O₂
Molecular Weight	312.45 g/mol
Synonyms	13-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one; 17α-Ethynyl-13β-ethyl-17β-hydroxy-4,5-didehydro-5(10)-gon-3-one; D-(-)-13β-Ethyl-17α-ethynyl-17β-hydroxy-4,5-seco-5(10)-gon-3-one; 4,5-Seco-5(10)-norgestrel; Dehydrodihydronorgestrel; Norgestrel Impurity; Norgestrel Related Compound
EINECS	Contact for details

Quality Control

Our 5(6)-Dehydro-4(5)-Dihydro D-(-)-Norgestrel is produced and tested under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.