Description

tert-Butyl (R)-2-Hydroxy-4-Methylpentanoate is a high-purity chiral intermediate of significant importance in asymmetric synthesis. Its value lies in its role as a key building block for constructing complex molecules with defined stereochemistry. This compound is primarily needed by pharmaceutical, agrochemical, and fine chemical R&D and production teams for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in protease inhibitor and other therapeutic classes.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereoisomers exhibit enhanced biological activity.
• Fine Chemical Production: Serves as a building block for fragrances, flavors, and advanced materials requiring precise stereochemical control.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in academic and industrial research focused on developing new catalytic methodologies.
• Peptidomimetics: Used in the construction of peptide analogs and mimetics for drug discovery programs.

Basic Information

Product Name	tert-Butyl (R)-2-Hydroxy-4-Methylpentanoate
CAS No.	19892-92-3
Molecular Formula	C10H20O3
Molecular Weight	188.26 g/mol
Synonyms	(R)-2-Hydroxy-4-methylpentanoic acid tert-butyl ester; (R)-tert-Butyl 2-hydroxy-4-methylpentanoate; (R)-HMPB-OtBu; (R)-Leucine tert-butyl ester derivative; (R)-2-Hydroxyisocaproic acid tert-butyl ester; (R)-HICA-OtBu; tert-Butyl (R)-2-hydroxy-4-methylvalerate
EINECS	Contact for details

Quality Control

Our tert-Butyl (R)-2-Hydroxy-4-Methylpentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications for identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.