Description

[3-[Bis(2-Chloroethyl)Amino]-4-Methylphenyl]Phosphonic Acid CAS NO 19768-76-4 is a specialized organophosphorus compound featuring a nitrogen mustard moiety, making it a valuable intermediate for advanced chemical synthesis. Its bifunctional structure allows it to act as a key building block in the development of targeted pharmaceuticals and sophisticated agrochemicals. This high-purity intermediate is essential for research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to develop novel active ingredients with specific biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of nitrogen mustard-based chemotherapeutic agents and targeted cancer therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and plant growth regulators that leverage its phosphonic acid and alkylating properties.
• Bioconjugation & Linker Chemistry: Functions as a versatile linker molecule for attaching cytotoxic agents to antibodies, peptides, or other targeting moieties in Antibody-Drug Conjugate (ADC) development.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for creating specialty polymers with specific degradation profiles or bioactive surfaces.
• Chemical Biology Research: Employed as a tool compound in biochemical studies to investigate alkylation mechanisms and enzyme inhibition.
• Ligand for Metal Complexation: The phosphonic acid group allows it to act as a chelating ligand in the preparation of metal-organic frameworks (MOFs) or catalysts.

Basic Information

Product Name	[3-[Bis(2-Chloroethyl)Amino]-4-Methylphenyl]Phosphonic Acid
CAS No.	19768-76-4
Molecular Formula	C13H20Cl2NO3P
Molecular Weight	364.18 g/mol
Synonyms	4-Methyl-3-[bis(2-chloroethyl)amino]benzenephosphonic Acid; Phosphonic Acid, P-[3-[bis(2-chloroethyl)amino]-4-methylphenyl]-; 3-[Bis(2-chloroethyl)amino]-4-methylbenzenephosphonic Acid; N,N-Bis(2-chloroethyl)-4-methyl-3-phosphonobenzeneamine; 4-Methyl-3-(N,N-bis(2-chloroethyl)amino)phenylphosphonic Acid; Nitrogen Mustard Phosphonic Acid Derivative; 3-(Bis(2-chloroethyl)amino)-4-methylphenylphosphonic Acid
EINECS	Contact for details

Quality Control

Our production of [3-[Bis(2-Chloroethyl)Amino]-4-Methylphenyl]Phosphonic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets precise customer specifications. Certificates of Analysis (COA) detailing all critical quality attributes are provided and can be tailored to support regulatory filings for pharmaceutical or agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.