Description

δ-5(10)-Norethindrone Acetate is a key synthetic steroid intermediate of significant importance in pharmaceutical manufacturing. This compound is valued for its role as a versatile precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly progestins and other steroid-based therapeutics. It is primarily required by pharmaceutical R&D laboratories and production facilities engaged in the development and commercial-scale synthesis of hormonal drugs and related fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of norethindrone (norethisterone) and its derivatives, which are widely used in hormonal contraceptives and hormone replacement therapies.
• Progestogen Synthesis: Serves as a key precursor for manufacturing various 19-norsteroid progestogens, essential for developing treatments for endometriosis, menstrual disorders, and certain cancers.
• Steroid Research & Development: Used in academic and industrial research settings for exploring new steroid analogs and studying structure-activity relationships (SAR).
• Fine Chemical Production: Employed in the production of other high-value, complex steroid molecules for therapeutic and diagnostic applications.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	δ-5(10)-Norethindrone Acetate
CAS No.	19637-28-6
Molecular Formula	C₂₂H₂₈O₃
Molecular Weight	340.46 g/mol
Synonyms	19-Nor-17α-pregn-5(10)-en-20-yn-3-one, 17-acetate; 17α-Ethynyl-19-norandrost-5(10)-en-17β-ol-3-one acetate; 5(10)-Estren-17α-ethynyl-17β-ol-3-one acetate; δ5(10)-19-Norethisterone Acetate; 5(10)-Norethindrone Acetate; 19-Norpregna-5(10)-en-20-yn-3-one, 17-(acetyloxy)-, (17α)-; Norethindrone δ-5(10) Acetate
EINECS	Contact for details

Quality Control

Our δ-5(10)-Norethindrone Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets exacting standards suitable for pharmaceutical intermediate use. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.