Description

(4S,5R)-4,5-Diphenyl-1,3-Dioxolane-2-One is a high-purity chiral building block and intermediate of significant value in asymmetric synthesis. Its defined stereochemistry makes it a critical precursor for the production of enantiomerically pure pharmaceuticals and advanced materials. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific chiral centers into complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) requiring specific (S,S) or (R,R) configurations.
• Asymmetric Catalyst Ligand Precursor: Used in the development and manufacture of chiral ligands for transition metal catalysis.
• Agrochemical Synthesis: Serves as a building block for creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Employed in the multi-step synthesis of complex natural products, flavors, and fragrances.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and stereoselective transformations.
• Material Science: Potential monomer or precursor for chiral polymers and advanced functional materials.

Basic Information

Item	Details
Product Name	(4S,5R)-4,5-Diphenyl-1,3-Dioxolane-2-One
CAS No.	19456-17-8
Molecular Formula	C15H12O3
Molecular Weight	240.26 g/mol
Synonyms	(4S,5R)-4,5-Diphenyl-1,3-dioxolan-2-one; (S,S)-4,5-Diphenyl-1,3-dioxolan-2-one; (-)-(4S,5R)-4,5-Diphenyl-2-oxo-1,3-dioxolane; (4S,5R)-Diphenyl ethylene carbonate; Chiral diphenyl ethylene carbonate; (S,S)-Diphenyl ethylene carbonate; Solketal phenyl carbonate derivative; 1,3-Dioxolan-2-one, 4,5-diphenyl-, (4S,5R)-
EINECS	Contact for details

Quality Control

Our (4S,5R)-4,5-Diphenyl-1,3-Dioxolane-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.