Description

(2S,5R)-Tetrahydrothiophene-2,5-Dicarboxylic Acid Dimethyl Ester is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. This compound matters as a versatile synthon for constructing complex sulfur-containing heterocycles and bioactive molecules with precise stereochemistry. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Key chiral intermediate in the synthesis of novel pharmaceutical active ingredients (APIs), particularly for sulfur-based drug candidates.
• Building block for the development of asymmetric catalysts and ligands used in stereoselective transformations.
• Precursor in the research and production of agrochemicals, such as herbicides and fungicides with specific stereochemical requirements.
• Starting material for the synthesis of complex heterocyclic compounds and natural product analogs in academic and industrial R&D.
• Intermediate in fine chemical production for flavor and fragrance ingredients requiring specific enantiomeric purity.
• Used in material science research for the preparation of specialty polymers and functionalized materials.

Basic Information

Product Name	(2S,5R)-Tetrahydrothiophene-2,5-Dicarboxylic Acid Dimethyl Ester
CAS No.	19438-91-6
Molecular Formula	C8H12O4S
Molecular Weight	204.24 g/mol
Synonyms	Dimethyl (2S,5R)-Tetrahydrothiophene-2,5-dicarboxylate; (2S,5R)-Tetrahydrothiophene-2,5-dicarboxylic acid dimethyl ester; (2S,5R)-THF-2,5-Dicarboxylic Acid Dimethyl Ester; (2S,5R)-2,5-Bis(methoxycarbonyl)tetrahydrothiophene; L-(+)-Tetrahydrothiophene-2,5-dicarboxylic Acid Dimethyl Ester; (2S,5R)-Dimethyl Tetrahydrothiophene-2,5-dicarboxylate; Stereoisomer of Tetrahydrothiophenedicarboxylic Acid Dimethyl Ester
EINECS	Contact for details

Quality Control

Our (2S,5R)-Tetrahydrothiophene-2,5-Dicarboxylic Acid Dimethyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, NMR, and GC-MS, to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.