Description

Trimethylsilyl Acetylenecarboxylate is a versatile organosilicon reagent featuring both a silyl-protected alkyne and an ester functional group. This bifunctional nature makes it a valuable building block for the synthesis of complex organic molecules, particularly in pharmaceutical and advanced materials research. It is primarily used by R&D chemists and process development scientists in the fine chemical, agrochemical, and electronics industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of acetylene-containing active pharmaceutical ingredients (APIs) and bioactive compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators requiring alkyne motifs.
• Material Science: Building block for polymers and advanced materials, including conductive polymers and liquid crystals.
• Cross-Coupling Reactions: Serves as a substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions.
• Click Chemistry: Precursor for Huisgen 1,3-dipolar cycloaddition (azide-alkyne cycloaddition) reactions to create triazole linkages.
• Organic Synthesis Reagent: Used for the introduction of the trimethylsilyl-protected ethynyl group and carboxylate ester functionality in multi-step syntheses.

Basic Information

Product Name	Trimethylsilyl Acetylenecarboxylate
CAS No.	19232-22-5
Molecular Formula	C8H12O2Si
Molecular Weight	168.26 g/mol
Synonyms	Trimethylsilyl Propiolate; (Trimethylsilyl)propiolic Acid Ester; Propiolic Acid Trimethylsilyl Ester; TMS Propiolate; 2-Trimethylsilylethynylcarboxylate; Acetylenecarboxylic Acid Trimethylsilyl Ester; Trimethylsilyl Ethynylcarboxylate
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Acetylenecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.