Description

Trimethylsilyldulcitol is a specialized organosilicon derivative of the sugar alcohol dulcitol, primarily utilized as a key synthetic intermediate and protecting group reagent. Its value lies in enabling complex organic syntheses, particularly in the pharmaceutical and fine chemical sectors, by providing a stable, silyl-protected form of the polyol scaffold. This compound is essential for research chemists and process development scientists working on nucleoside analogs, carbohydrate chemistry, and the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of nucleoside analogs and other active pharmaceutical ingredients (APIs).
• Carbohydrate Chemistry Research: Used as a protected derivative of dulcitol for studying glycosylation reactions and polyol transformations.
• Fine Chemical Synthesis: Serves as a versatile intermediate in the production of complex, high-value specialty chemicals.
• Protecting Group Reagent: The trimethylsilyl (TMS) groups act to protect hydroxyl functionalities during multi-step synthetic sequences.
• Process Development: Employed in route scouting and optimization for the scalable manufacturing of target molecules.
• Analytical Reference Standard: Used as a certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Trimethylsilyldulcitol
CAS No.	18919-39-6
Molecular Formula	C12H30O6Si2
Molecular Weight	326.54 g/mol
Synonyms	Dulcitol, hexakis-O-(trimethylsilyl)-; Hexa-O-trimethylsilyl-Dulcitol; 1,2,3,4,5,6-Hexakis-O-(trimethylsilyl)-D-glucitol; Galactitol, hexakis(trimethylsilyl) ether; Fully TMS-protected Dulcitol; TMS-Dulcitol; Per-TMS Dulcitol; Hexakis(trimethylsiloxy)hexane
EINECS	Contact for details

Quality Control

Our Trimethylsilyldulcitol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.