Description

n-(2-Nitrobenzoyl)-L-Proline is a specialized chiral building block and intermediate of significant interest in advanced organic synthesis. This compound matters for its role in the development of pharmaceuticals and bioactive molecules, particularly where the stereochemistry of the proline moiety is critical. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and constrained peptides where proline derivatives are essential for modulating biological activity and stability.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric catalysis, enhancing enantioselectivity in chemical transformations.
• Agrochemical Synthesis: Employed in the development of advanced, enantiomerically pure agrochemicals to improve efficacy and reduce environmental impact.
• Biochemical Tool Compound: Utilized in academic and industrial research as a standard or probe for studying enzyme-substrate interactions and metabolic pathways.
• Fine Chemical Manufacturing: Integrated into multi-step synthetic routes for producing high-value, complex organic molecules with specific stereochemical requirements.

Basic Information

Product Name	n-(2-Nitrobenzoyl)-L-Proline
CAS No.	18877-33-3
Molecular Formula	C12H12N2O5
Molecular Weight	264.24 g/mol
Synonyms	L-Proline, 1-[(2-nitrobenzoyl)oxy]-; (S)-1-(2-Nitrobenzoyl)pyrrolidine-2-carboxylic acid; 2-Nitrobenzoic acid L-proline ester; N-(2-Nitrobenzoyl)-L-proline; N-(o-Nitrobenzoyl)-L-proline; (S)-N-(2-Nitrobenzoyl)proline; 18877-33-3; L-Proline, N-(2-nitrobenzoyl)-
EINECS	Contact for details

Quality Control

Our n-(2-Nitrobenzoyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.