Description

4-(4-(Bis-(2-Chloroethyl)Amino)Benzylidene-2-Phenyl-Oxazoline-5-One is a specialized nitrogen mustard derivative with a benzylidene-oxazolone core structure. This compound is valued for its role as a key synthetic intermediate in the development of targeted pharmaceutical agents and advanced research chemicals. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for constructing complex molecules with potential biological activity.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nitrogen mustard-based prodrugs and targeted chemotherapeutic agents.
• Anticancer Research: Serves as a precursor for compounds being investigated for their alkylating properties and cytotoxicity in oncology research.
• Bioconjugation Chemistry: Used in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems due to its reactive chloroethyl groups.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of experimental drug candidates.
• Fine Chemical Synthesis: Acts as a versatile intermediate for creating complex heterocyclic compounds and specialized dyes or pigments.
• Biochemical Tool Compound: Utilized in laboratory settings to study DNA alkylation mechanisms and cellular response pathways.

Basic Information

Product Name	4-(4-(Bis-(2-Chloroethyl)Amino)Benzylidene-2-Phenyl-Oxazoline-5-One
CAS No.	18776-75-5
Molecular Formula	C20H20Cl2N2O2
Molecular Weight	391.29 g/mol
Synonyms	4-[4-[Bis(2-chloroethyl)amino]benzylidene]-2-phenyl-4,5-dihydro-1,3-oxazol-5-one; 2-Phenyl-4-[4-[bis(2-chloroethyl)amino]benzylidene]-5-oxazolone; 4-(4-(Bis(2-chloroethyl)amino)benzylidene)-2-phenyl-2-oxazolin-5-one; Nitrogen Mustard Benzylidene Oxazolone Derivative; Oxazolone Nitrogen Mustard; 18776-75-5; Benzylidene Oxazolone Mustard
EINECS	Contact for details

Quality Control

Our 4-(4-(Bis-(2-Chloroethyl)Amino)Benzylidene-2-Phenyl-Oxazoline-5-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from oxidizing agents and strong bases. Due to its light-sensitive and easily oxidized nature, minimize exposure to air and light during handling.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.