Description

Ethyl 3-Phenyl-n-[1-[(Phenylmethoxy)Carbonyl]-L-Prolyl]-L-Alaninate CAS NO 18532-06-4 is a sophisticated chiral building block and protected dipeptide derivative. This compound is of significant value in advanced pharmaceutical research and development, particularly in the synthesis of complex peptide-based therapeutics and enzyme inhibitors. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating novel drug candidates and fine-tuning synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs, including protease inhibitors and hormone analogs.
• Protease Inhibitor Synthesis: Serves as a critical precursor in the construction of complex molecules designed to inhibit specific enzymatic targets.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative for the controlled, sequential assembly of custom peptides.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new bioactive compounds and optimize lead molecules.
• Bioconjugation and Labeling: The reactive ester group makes it suitable for coupling reactions in the preparation of peptide conjugates for diagnostic or therapeutic purposes.
• Academic & Institutional R&D: A valuable reagent for universities and research institutes studying peptide chemistry, asymmetric synthesis, and drug discovery methodologies.

Basic Information

Product Name	Ethyl 3-Phenyl-n-[1-[(Phenylmethoxy)Carbonyl]-L-Prolyl]-L-Alaninate
CAS No.	18532-06-4
Molecular Formula	C26H30N2O5
Molecular Weight	450.53 g/mol
Synonyms	Ethyl L-Alanyl-N-[1-[(benzyloxy)carbonyl]-L-prolyl]-3-phenylalaninate; Z-L-Pro-L-Ala-3-Phe-OEt; N-[(Benzyloxy)carbonyl]-L-prolyl-L-alanine 3-phenyl ethyl ester; CBZ-L-Pro-L-Ala-3-Phe-OEt; Z-L-Pro-L-Ala-Phe(3)-OEt; L-Alanine, N-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-, 3-phenyl-, ethyl ester; Ethyl 3-phenylalanyl-N-[1-(benzyloxycarbonyl)-L-prolyl]-L-alaninate
EINECS	Contact for details

Quality Control

Our Ethyl 3-Phenyl-n-[1-[(Phenylmethoxy)Carbonyl]-L-Prolyl]-L-Alaninate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.