Description

Methyl 2-(Acetylamino)-3-O,4-O,6-o-Tris(Trimethylsilyl)-2-Deoxy-α-D-Glucopyranoside CAS NO 18434-96-3 is a key protected carbohydrate derivative, specifically a per-silylated N-acetylglucosamine methyl glycoside, designed for advanced synthetic applications. This compound is essential for researchers and process chemists requiring a stable, non-reactive intermediate with multiple hydroxyl groups protected as trimethylsilyl (TMS) ethers. It is primarily utilized in the pharmaceutical, biotechnology, and fine chemical synthesis sectors for constructing complex glycoconjugates, oligosaccharides, and bioactive molecules.

Application

• Glycochemistry & Oligosaccharide Synthesis: Serves as a crucial, protected building block for the controlled, stepwise assembly of complex carbohydrate structures.
• Pharmaceutical Intermediate: Used in the research and development of glycosidase inhibitors, antiviral agents, and other therapeutics targeting carbohydrate-processing pathways.
• Bioconjugation & Probe Development: Acts as a precursor for synthesizing labeled sugars or glycoconjugates used in biochemical assays and diagnostic tools.
• Chemical Biology Research: Employed in studying glycosylation processes, enzyme mechanisms, and carbohydrate-protein interactions.
• Fine Chemical Synthesis: Provides a versatile intermediate for creating specialty chemicals with specific stereochemical and functional group requirements.

Basic Information

Item	Detail
Product Name	Methyl 2-(Acetylamino)-3-O,4-O,6-o-Tris(Trimethylsilyl)-2-Deoxy-α-D-Glucopyranoside
CAS No.	18434-96-3
Molecular Formula	C18H41NO6Si3
Molecular Weight	463.78 g/mol
Synonyms	Methyl 2-Acetamido-3,4,6-tri-O-trimethylsilyl-2-deoxy-α-D-glucopyranoside; Methyl 2-Acetamido-2-deoxy-3,4,6-tri-O-(trimethylsilyl)-α-D-glucopyranoside; α-Methyl N-acetyl-3,4,6-tri-O-trimethylsilyl-D-glucosaminide; 2-Acetamido-1,3,4,6-tetra-O-trimethylsilyl-2-deoxy-α-D-glucopyranose methyl glycoside; Per-TMS Methyl N-Acetyl-α-D-glucosaminide; TMS-protected Methyl GlcNAc; 18434-96-3
EINECS	Contact for details

Quality Control

Our Methyl 2-(Acetylamino)-3-O,4-O,6-o-Tris(Trimethylsilyl)-2-Deoxy-α-D-Glucopyranoside is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions, preferably in a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.