Description

5-(4-Chlorophenyl)Tetrahydrofuran-2(3H)-One is a high-purity, versatile heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring a tetrahydrofuranone ring fused with a chlorophenyl group, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and plant growth regulators, leveraging the bioactivity of the chlorophenyl moiety.
• Organic Synthesis Building Block: Used in academic and industrial R&D for constructing complex heterocycles, lactones, and other fine chemicals via ring-opening, reduction, or functional group transformation reactions.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced materials with specific thermal or optical properties.

Basic Information

Product Name	5-(4-Chlorophenyl)Tetrahydrofuran-2(3H)-One
CAS No.	18410-18-9
Molecular Formula	C10H9ClO2
Molecular Weight	196.63 g/mol
Synonyms	5-(4-Chlorophenyl)dihydrofuran-2(3H)-one; 4-Chloro-γ-phenyl-γ-butyrolactone; γ-(4-Chlorophenyl)-γ-butyrolactone; 5-(p-Chlorophenyl)tetrahydro-2-furanone; 3,4-Dihydro-5-(4-chlorophenyl)-2(3H)-furanone; 18410-18-9; p-Chlorophenyl butyrolactone
EINECS	Contact for details

Quality Control

Our 5-(4-Chlorophenyl)Tetrahydrofuran-2(3H)-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78°C - 82°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.