Description

Methyl Tri-o-Acetyl-1-Naphthol Glucuronate is a specialized glucuronide derivative, a key intermediate in the synthesis of complex organic molecules and pharmaceutical agents. Its value lies in its role as a protected glucuronic acid moiety, which is crucial for modifying the solubility, stability, and metabolic profile of target compounds. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries working on prodrug design, metabolite synthesis, and advanced glycosylation reactions.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of prodrugs and active pharmaceutical ingredients (APIs) designed for targeted drug delivery and improved bioavailability.
• Metabolite Reference Standard: Used in analytical laboratories as a reference compound for drug metabolism and pharmacokinetic (DMPK) studies to identify and quantify glucuronidated metabolites.
• Bioconjugation Chemistry: Serves as a key reagent for attaching glucuronic acid groups to biomolecules, peptides, or small molecules to alter their physicochemical properties.
• Glycochemistry Research: A valuable tool in academic and industrial research focused on synthesizing complex carbohydrates, glycoconjugates, and studying glycosyltransferase enzymes.
• Agrochemical Synthesis: Potential intermediate in the development of novel herbicides or pesticides where glucuronidation affects compound stability or environmental fate.
• Diagnostic Agent Development: Can be utilized in the design of contrast agents or diagnostic probes where glucuronide moieties are used for enzyme-activated targeting or signal amplification.

Basic Information

Product Name	Methyl Tri-o-Acetyl-1-Naphthol Glucuronate
CAS No.	18404-55-2
Molecular Formula	C22H24O11
Molecular Weight	464.42 g/mol
Synonyms	Methyl (2,3,4-Tri-O-acetyl-1-O-(1-naphthyl)-β-D-glucopyranosid)uronate; 1-Naphthyl 2,3,4-Tri-O-acetyl-β-D-glucopyranosiduronic Acid Methyl Ester; Methyl 2,3,4-Tri-O-acetyl-1-O-(1-naphthyl)-β-D-glucopyranuronate; 1-Naphthol Glucuronate Methyl Ester Triacetate; Triacetyl Methyl Naphthol Glucuronate; β-D-Glucopyranosiduronic acid, methyl 2,3,4-tri-O-acetyl-1-O-1-naphthalenyl-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to strict quality management protocols to support our customers' research and cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.