Description

3-Methyl-1-Butynyltrimethylsilane is a specialized organosilicon compound featuring a reactive terminal alkyne group protected by a trimethylsilyl moiety. This unique structure makes it a valuable building block in advanced organic synthesis, particularly for the controlled introduction of the 3-methylbut-1-ynyl unit. It is primarily utilized by pharmaceutical, agrochemical, and advanced materials researchers for constructing complex molecular architectures, including active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) via Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the alkynylsilane group acts as a protected alkyne handle.
• Material Science Research: Serves as a monomer or precursor in the development of silicon-containing polymers and advanced organic electronic materials.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for the stereoselective construction of carbon-carbon bonds and the introduction of functionalized alkynyl groups.
• Ligand and Catalyst Preparation: Used to synthesize specialized ligands for transition metal catalysis and organometallic complexes.
• Fine Chemical Production: Acts as a versatile intermediate in the manufacture of flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Item	Detail
Product Name	3-Methyl-1-Butynyltrimethylsilane
CAS No.	18388-07-3
Molecular Formula	C8H16Si
Molecular Weight	140.30 g/mol
Synonyms	Trimethyl(3-methylbut-1-yn-1-yl)silane; (3-Methyl-1-butyn-1-yl)trimethylsilane; 3-Methyl-1-butynyltrimethylsilane; 1-Trimethylsilyl-3-methyl-1-butyne; 3-Methyl-1-(trimethylsilyl)-1-butyne; TMS-3-methyl-1-butyne; 3-Methylbut-1-yn-1-yltrimethylsilane
EINECS	Contact for details

Quality Control

Our 3-Methyl-1-Butynyltrimethylsilane is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Containers should be kept tightly sealed when not in use to prevent evaporation and potential moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.