Description

Spiro[3.4]Octane-2-Carboxylic Acid CAS NO 18386-63-5 is a specialized spirocyclic carboxylic acid building block of significant interest in advanced organic synthesis. Its unique, rigid spirocyclic framework makes it a valuable precursor for constructing complex molecular architectures with defined three-dimensional shapes. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where its spiro structure can contribute to unique biological activity and metabolic stability.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Acts as a monomer or cross-linking agent for creating polymers with specific thermal and mechanical properties.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying enzyme function and protein-protein interactions due to its conformational restraint.
• Flavor and Fragrance Chemistry: Potential intermediate for synthesizing novel musk or amber odorants with complex, long-lasting scent profiles.

Basic Information

Product Name	Spiro[3.4]Octane-2-Carboxylic Acid
CAS No.	18386-63-5
Molecular Formula	C9H14O2
Molecular Weight	154.21 g/mol
Synonyms	Spiro[3.4]octane-2-carboxylic acid; 2-Spiro[3.4]octanecarboxylic acid; 2-Carboxyspiro[3.4]octane; 1-Oxaspiro[2.5]octane-5-carboxylic acid (tautomeric form); Spirocyclic C9 acid; Bicyclo[3.3.0]octane-2-carboxylic acid derivative
EINECS	Contact for details

Quality Control

Our Spiro[3.4]Octane-2-Carboxylic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.