Description

Bis(Trimethylsilyl)Sulfate is a versatile and highly reactive organosilicon reagent, primarily used as a powerful silylating agent and a source of the sulfate anion. Its core value proposition lies in its ability to efficiently introduce trimethylsilyl (TMS) protecting groups and facilitate sulfation reactions under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the synthesis of complex organic molecules, intermediates, and specialty polymers.

Application

• Pharmaceutical Synthesis: Key reagent for the protection of hydroxyl groups and the synthesis of sulfate esters in active pharmaceutical ingredients (APIs) and intermediates.
• Agrochemical Manufacturing: Used in the production of herbicides, fungicides, and plant growth regulators requiring silylation or sulfation steps.
• Polymer & Material Science: Acts as a cross-linking agent or surface modifier in the development of silicone-based polymers and advanced composite materials.
• Analytical Chemistry: Employed as a derivatization agent in gas chromatography (GC) and mass spectrometry (MS) to enhance the volatility and detectability of polar compounds.
• Fine Chemical Production: Facilitates the synthesis of specialty chemicals, flavors, and fragrances where selective silylation is required.
• Laboratory Research: A valuable tool in organic synthesis for chemists exploring new methodologies involving silyl ether formation or sulfate transfer reactions.

Basic Information

Product Name	Bis(Trimethylsilyl)Sulfate
CAS No.	18306-29-1
Molecular Formula	C6H18O4SSi2
Molecular Weight	242.44 g/mol
Synonyms	Sulfuric Acid Bis(trimethylsilyl) Ester; Hexamethyldisiloxane Sulfate; TMS Sulfate; Bis(TMS) Sulfate; 1,1,1,3,3,3-Hexamethyl-2-(sulfatooxy)disiloxane; Sulfuric Acid Hexamethyldisiloxane Ester; Sulfatooxytrimethylsilane Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyl)Sulfate is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including assay by titration and impurity profiling, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (Titration)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Chloride (Cl)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.