Description

4-(Trimethylsilyl)Pyridine is a versatile organosilicon compound featuring a pyridine ring substituted with a trimethylsilyl group, offering unique reactivity and protective properties. This compound is a valuable silylating agent and synthetic intermediate, prized for its ability to introduce the trimethylsilyl moiety into target molecules, enhancing their lipophilicity and stability. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing active ingredients, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly as a protecting group for hydroxyl or amine functionalities during complex multi-step reactions.
• Agrochemical Synthesis: Serves as a key building block in the production of advanced pesticides, herbicides, and plant growth regulators.
• Organometallic Chemistry & Catalysis: Acts as a ligand precursor or a modifying agent for metal complexes used in homogeneous catalysis.
• Material Science: Employed in the surface modification of silica and other inorganic materials, or as a monomer/precursor for silicon-containing polymers.
• Chemical Research & Development: A fundamental reagent in organic synthesis labs for nucleophilic substitution reactions and the preparation of silyl ethers.
• Protecting Group Strategy: The trimethylsilyl group is used to temporarily mask reactive sites on complex molecules, enabling selective transformations.

Basic Information

Product Name	4-(Trimethylsilyl)Pyridine
CAS No.	18301-46-7
Molecular Formula	C8H13NSi
Molecular Weight	151.28 g/mol
Synonyms	4-(Trimethylsilyl)pyridine; 4-Pyridyltrimethylsilane; 4-TMS-Pyridine; γ-(Trimethylsilyl)pyridine; Pyridine, 4-(trimethylsilyl)-; 4-Trimethylsilylpyridine; NSC 163082; 4-Pyridyltrimethylsilane
EINECS	242-205-5

Quality Control

Our 4-(Trimethylsilyl)Pyridine is produced under stringent quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.