Description

3-(Trimethylsilyl)Propanoic Acid Methyl Ester is a versatile organosilicon compound that serves as a key building block and protecting group reagent in advanced organic synthesis. Its value lies in its ability to introduce the trimethylsilylpropanoate moiety, which can be manipulated under mild conditions, offering chemists a powerful tool for constructing complex molecules. This reagent is particularly essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly where silicon-containing groups are needed for temporary protection or to modulate pharmacokinetic properties.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced pesticides and herbicides, where its silicon group can enhance stability or bioavailability.
• Polymer & Material Science: Acts as a monomer or modifying agent in the production of specialty silicones and silicon-based polymers for coatings, adhesives, and advanced materials.
• Organic Synthesis Reagent: Employed as a protecting group for carboxylic acids or as a silicon-based linker in multi-step synthetic routes, including peptide and natural product synthesis.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions, such as Hiyama couplings, as an organosilicon nucleophile.
• Chemical Research & Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic methodologies and constructing novel molecular architectures.

Basic Information

Product Name	3-(Trimethylsilyl)Propanoic Acid Methyl Ester
CAS No.	18296-04-3
Molecular Formula	C7H16O2Si
Molecular Weight	160.29 g/mol
Synonyms	Methyl 3-(Trimethylsilyl)Propanoate; Methyl 3-(Trimethylsilyl)Propionate; 3-(Trimethylsilyl)Propionic Acid Methyl Ester; Methyl Trimethylsilylpropionate; (3-Methoxy-3-oxopropyl)trimethylsilane; Trimethylsilylpropanoic Acid Methyl Ester; TMS-Propanoate Methyl Ester; Silane, (3-methoxy-3-oxopropyl)trimethyl-
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsilyl)Propanoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and IR spectroscopy, to ensure high chemical purity and consistency. Certificates of Analysis (COA) documenting identity, assay, and impurity profiles are available for every shipment. We support compliance with relevant guidelines for use in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed when not in use to prevent moisture absorption and maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Density (at 20°C)	0.89 - 0.91 g/mL
Refractive Index (n20D)	1.410 - 1.415

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.