Description

o-Trimethylsilyl Chloroacetate is a versatile organosilicon reagent featuring a reactive chloroacetate group protected by a trimethylsilyl moiety. This compound is valued for its dual functionality, serving as a key building block in the synthesis of complex molecules where it acts as a protected glycolic acid equivalent or a silylating agent. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced material sectors for constructing active pharmaceutical ingredients (APIs), specialty intermediates, and functional polymers.

Application

• Pharmaceutical Intermediate: A crucial reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing protected carboxylic acid or hydroxyacetic acid fragments.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require chloroacetate or silyl-protected functional groups.
• Peptide & Protein Modification: Employed as a silylating agent to protect reactive functional groups during complex peptide synthesis and bioconjugation processes.
• Polymer & Material Science: Serves as a monomer or functionalization agent in the creation of specialty silicones, coatings, and advanced polymeric materials with tailored properties.
• Organic Synthesis Reagent: Acts as a versatile building block for nucleophilic substitution reactions, enabling the efficient construction of esters, ethers, and complex carbon chains in laboratory and pilot-scale synthesis.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed cross-coupling reactions (e.g., Stille, Suzuki) as a source of the chloroacetate moiety for constructing complex molecular architectures.

Basic Information

Product Name	o-Trimethylsilyl Chloroacetate
CAS No.	18293-71-5
Molecular Formula	C5H11ClO2Si
Molecular Weight	166.68 g/mol
Synonyms	Chloroacetic Acid Trimethylsilyl Ester; Trimethylsilyl Chloroacetate; (Chloroacetoxy)trimethylsilane; Chloroacetic Acid O-Trimethylsilyl Ester; TMS Chloroacetate; NSC 163083; Acetic Acid, 2-Chloro-, Trimethylsilyl Ester; Silane, (Chloroacetoxy)trimethyl-
EINECS	Contact for details

Quality Control

Our o-Trimethylsilyl Chloroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Chloroacetic Acid (Titration)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.