Description

Trimethylsilyl Bromoacetate is a versatile organosilicon reagent featuring a reactive bromoacetate moiety protected by a trimethylsilyl group. This compound is crucial for introducing the bromoacetate functional group under mild conditions, enabling precise synthetic modifications in complex molecule construction. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in peptide synthesis, polymer modification, and as a key building block for active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis & Modification: Used as a reagent for the alkylation of cysteine residues or the introduction of bromoacetyl groups for conjugation and linker chemistry.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Polymer & Material Science: Employed in the functionalization of polymers and surfaces to introduce reactive bromoacetate handles for further chemical grafting.
• Agrochemical Synthesis: Utilized in the production of certain herbicides and plant growth regulators requiring bromoacetate derivatives.
• Crosslinking Agent: Acts as a bifunctional reagent for crosslinking proteins, peptides, or other biomolecules in biochemical research.
• Ligand & Catalyst Preparation: Used in the synthesis of specialized ligands and organometallic catalysts.
• Protecting Group Strategy: The trimethylsilyl group can act as a protecting group for carboxylic acids in multi-step synthetic sequences.

Basic Information

Product Name	Trimethylsilyl Bromoacetate
CAS No.	18291-80-0
Molecular Formula	C7H15BrO2Si
Molecular Weight	239.18 g/mol
Synonyms	Bromoacetic Acid Trimethylsilyl Ester; (Bromoacetoxy)trimethylsilane; Trimethylsilyl 2-Bromoacetate; Bromoacetic Acid TMS Ester; TMS Bromoacetate; Silane, (bromoacetoxy)trimethyl-; Acetic acid, 2-bromo-, trimethylsilyl ester
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Bromoacetate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.