Description

Methylphosphonic Acid Bis(Trimethylsilyl) Ester is a high-purity organosilicon reagent and a key protected intermediate in synthetic organic chemistry. Its primary value lies in its role as a versatile silylating agent and a protected form of methylphosphonic acid, enabling precise chemical transformations under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the synthesis of complex molecules, organophosphorus compounds, and as a precursor in specialized catalysis.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing phosphorus-based functional groups or requiring silyl protection strategies.
• Agrochemical Synthesis: Serves as a key building block for creating novel herbicides, insecticides, and plant growth regulators with phosphonate backbones.
• Organometallic Chemistry & Catalysis: Acts as a ligand precursor or a modifying agent for metal catalysts, influencing reactivity and selectivity in coupling reactions.
• Polymer & Material Science: Employed in the production of specialty polymers, flame retardants, and surface-modifying agents where phosphonate groups are required.
• Chemical Derivatization: Utilized in analytical chemistry for the derivatization of sensitive or polar compounds (e.g., acids, alcohols) to improve their volatility for GC-MS analysis.
• Laboratory Reagent: A valuable reagent for academic and industrial R&D in synthetic methodology development and complex molecule construction.

Basic Information

Product Name	Methylphosphonic Acid Bis(Trimethylsilyl) Ester
CAS No.	18279-83-9
Molecular Formula	C7H21O3PSi2
Molecular Weight	240.38 g/mol
Synonyms	Bis(trimethylsilyl) Methylphosphonate; Methylphosphonic Acid Bis(trimethylsilyl) Ester; Methylphosphonic Acid, Bis(trimethylsilyl) Ester; Trimethylsilyl Methylphosphonate; O,O-Bis(trimethylsilyl) Methylphosphonate; Methylphosphonic Acid Di(trimethylsilyl) Ester; Phosphonic Acid, Methyl-, Bis(trimethylsilyl) Ester
EINECS	Contact for details

Quality Control

Our production of Methylphosphonic Acid Bis(Trimethylsilyl) Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including NMR, GC, and HPLC to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (NMR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.