Description

2-(Trimethylsilyl)-1H-Pyrrole is a versatile organosilicon-protected pyrrole derivative, a key building block in advanced organic synthesis. Its primary value lies in its ability to act as a masked pyrrole anion, enabling selective functionalization at the nitrogen or carbon positions under mild conditions, which is crucial for constructing complex heterocyclic systems. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediates: Serves as a critical precursor in the synthesis of drug candidates, particularly those containing complex pyrrole or indole cores found in various therapeutic agents.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the pyrrole moiety is a key structural feature for biological activity.
• Material Science & Organic Electronics: Acts as a monomer or functionalization agent in the production of conductive polymers, organic semiconductors, and advanced materials for optoelectronic devices.
• Catalyst & Ligand Development: Employed to synthesize novel N-heterocyclic carbene (NHC) precursors, phosphine ligands, and other organometallic catalysts.
• Fine Chemical Synthesis: Utilized in multi-step synthetic routes for natural product synthesis, dyes, and other high-value specialty chemicals.
• Protecting Group Strategy: The trimethylsilyl (TMS) group effectively protects the pyrrole nitrogen, allowing for selective reactions on the ring carbons in complex molecular constructions.

Basic Information

Product Name	2-(Trimethylsilyl)-1H-Pyrrole
CAS No.	18276-13-6
Molecular Formula	C7H13NSi
Molecular Weight	139.27 g/mol
Synonyms	1H-Pyrrole, 2-(trimethylsilyl)-; 2-Trimethylsilylpyrrole; 2-TMS-pyrrole; N-Trimethylsilylpyrrole; Pyrrole, 2-(trimethylsilyl)-; 2-(Trimethylsilyl)pyrrole; (Trimethylsilyl)pyrrole; TMS-Pyrrole
EINECS	Contact for details

Quality Control

Every batch of 2-(Trimethylsilyl)-1H-Pyrrole is manufactured and tested under strict quality management systems. We ensure high purity and consistency through comprehensive analytical techniques including GC, HPLC, and NMR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.