Description

Silane, (Chloromethyl)(1,1-Dimethylethyl)Dimethyl- is a specialized organosilicon compound, CAS 18244-00-3, valued for its dual functionality as a chloromethyl and tert-butyldimethylsilyl (TBDMS) precursor. This compound matters as a versatile building block in advanced organic synthesis, enabling the introduction of protected functional groups and serving as a key reagent for silylation reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent for introducing the tert-butyldimethylsilyl (TBDMS) protecting group for alcohols and other sensitive functionalities during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Production: Serves as a building block in the synthesis of novel pesticides and herbicides, where its silane moiety can modify the physical properties and bioavailability of the final product.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the development of specialty silicones, silane-modified polymers, and surface coatings to impart specific chemical resistance or adhesion properties.
• Surface Modification: Utilized to functionalize inorganic surfaces (e.g., silica, glass) with organic chloromethyl groups, which can be further derivatized to create tailored surfaces for chromatography, catalysis, or sensors.
• Organic Synthesis Reagent: Employed in laboratory-scale and pilot-scale reactions for the selective protection/deprotection of hydroxyl groups, a critical step in complex natural product and fine chemical synthesis.

Basic Information

Item	Details
Product Name	Silane, (Chloromethyl)(1,1-Dimethylethyl)Dimethyl-
CAS No.	18244-00-3
Molecular Formula	C7H17ClSi
Molecular Weight	164.75 g/mol
Synonyms	(Chloromethyl)dimethyl(tert-butyl)silane; tert-Butyl(chloromethyl)dimethylsilane; (tert-Butyldimethylsilyl)methyl chloride; TBDMS-CH2Cl; (Chloromethyl)dimethyl(1,1-dimethylethyl)silane; (Chloromethyl)(tert-butyl)dimethylsilane; 1-(tert-Butyldimethylsilyl)methyl chloride
EINECS	Contact for details

Quality Control

Our (Chloromethyl)dimethyl(tert-butyl)silane is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and hydrolysis. Keep away from strong acids, bases, and oxidizing agents. Due to its high volatility and moisture-sensitive nature, containers must be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.