Description

Formic Acid Trimethylsilyl Ester is a versatile organosilicon reagent primarily used as a silylating agent and a protected form of formic acid. Its high volatility and reactivity make it a valuable intermediate for introducing the trimethylsilyl (TMS) group in complex organic syntheses and for derivatization in analytical chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and efficient silylation reactions.

Application

• Silylating Agent in Organic Synthesis: Used to protect hydroxyl and carboxyl groups, facilitating multi-step synthetic routes for complex molecules.
• Derivatization for Gas Chromatography (GC): Employed to convert polar, non-volatile analytes (like acids and alcohols) into volatile trimethylsilyl derivatives for improved separation and detection.
• Reagent in Peptide and Carbohydrate Chemistry: Acts as a coupling agent or protecting group in the synthesis of sensitive biomolecules.
• Precursor for Specialty Silanes: Serves as a starting material for the preparation of other functionalized organosilicon compounds.
• Catalyst and Additive: Can be utilized as a catalyst or reactive additive in polymerization and cross-linking reactions for silicone-based polymers.

Basic Information

Product Name	Formic Acid Trimethylsilyl Ester
CAS No.	18243-21-5
Molecular Formula	C4H10O2Si
Molecular Weight	118.20 g/mol
Synonyms	Trimethylsilyl Formate; Formic Acid Trimethylsilyl Ester; TMS Formate; Silyl Formate; Methylformic Acid Trimethylsilyl Ester; (Trimethylsilyloxy)methanone; Trimethylsilyl Methanoate
EINECS	Contact for details

Quality Control

Our Formic Acid Trimethylsilyl Ester is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, guaranteeing traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed when not in use and away from open flames and sources of ignition. Incompatible with strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.