Description

1-Chloro-2-[(Trimethylsilyl)Oxy]Propane is a versatile organosilicon reagent featuring a protected hydroxyl group and a reactive chloroalkyl chain. This bifunctional compound is valued for its role as a key synthetic intermediate in the preparation of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in fine chemical synthesis, where its unique structure enables selective transformations and the introduction of silicon-protected functionalities.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing propyl-linked side chains with protected alcohol moieties.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and plant growth regulators.
• Organosilicon Chemistry: Acts as a precursor for more complex siloxanes and silicone-based materials, leveraging the trimethylsilyl (TMS) protecting group.
• Material Science Research: Employed in the development of specialty polymers and surface-modifying agents where silicon incorporation is desired.
• Cross-Coupling Reactions: The chloro group can participate in various metal-catalyzed coupling reactions (e.g., Grignard, Negishi) for carbon-carbon bond formation.
• Ligand and Catalyst Preparation: Useful for synthesizing chiral auxiliaries or ligands used in asymmetric catalysis.

Basic Information

Item	Details
Product Name	1-Chloro-2-[(Trimethylsilyl)Oxy]Propane
CAS No.	18171-12-5
Molecular Formula	C6H15ClOSi
Molecular Weight	166.72 g/mol
Synonyms	1-Chloro-2-(trimethylsiloxy)propane; 2-(Trimethylsiloxy)propyl chloride; (1-Chloro-2-propoxy)trimethylsilane; Propane, 1-chloro-2-[(trimethylsilyl)oxy]-; TMS-protected 1-chloro-2-propanol; Trimethylsilyl 1-chloro-2-propyl ether; 1-Chloro-2-(O-trimethylsilyl)propane
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-[(Trimethylsilyl)Oxy]Propane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high purity and consistent performance. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.