Description

tert-Butyldimethylsilyl Chloride (TBDMS-Cl) is a highly versatile and widely used silylating agent in organic synthesis. Its primary value lies in its exceptional ability to protect hydroxyl groups, forming stable tert-butyldimethylsilyl (TBDMS) ethers that are resistant to a broad range of reaction conditions. This makes it an indispensable reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly in the multi-step synthesis of complex molecules like active pharmaceutical ingredients (APIs) and natural products.

Application

• Hydroxyl Group Protection in Pharmaceutical Synthesis: A cornerstone reagent for protecting primary and secondary alcohols during complex, multi-step syntheses of drug candidates and active pharmaceutical ingredients (APIs).
• Intermediate for Specialty Silicones: Serves as a key starting material or intermediate in the production of advanced silicone-based polymers and materials with tailored properties.
• Carbohydrate and Nucleoside Chemistry: Essential for the selective protection of sugar hydroxyl groups in the synthesis of nucleosides, nucleotides, and complex oligosaccharides.
• Natural Product and Steroid Synthesis: Used to protect sensitive alcohol functionalities during the total synthesis of complex natural products and steroids.
• Agrochemical Intermediate Manufacturing: Employed in the synthesis of advanced crop protection agents and other agrochemical intermediates where selective protection is required.
• Derivatization Agent for Analytical Chemistry: Used to prepare volatile derivatives of alcohols, phenols, and carboxylic acids for analysis by gas chromatography (GC) or GC-mass spectrometry (GC-MS).

Basic Information

Product Name	tert-Butyldimethylsilyl Chloride
CAS No.	18162-48-6
Molecular Formula	C6H15ClSi
Molecular Weight	150.72 g/mol
Synonyms	TBDMS-Cl; TBDMSCI; tert-Butylchlorodimethylsilane; Chloro(tert-butyl)dimethylsilane; Dimethyl-tert-butylsilyl chloride; TBS-Cl; (tert-Butyldimethylsilyl)chloride; tert-Butyldimethylchlorosilane
EINECS	242-052-9

Quality Control

Our tert-Butyldimethylsilyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for our customers' critical processes.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and hygroscopic nature, this product must be stored in a cool, dry, and well-ventilated place. For long-term stability, storage under an inert atmosphere (e.g., nitrogen or argon) in a refrigerator (2-8°C) is strongly recommended. Keep away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.