Description

Nitric Acid Trimethylsilyl Ester is a versatile organosilicon reagent primarily used as a powerful nitrating and silylating agent. This compound is critical for introducing nitro groups or trimethylsilyl protecting groups into complex organic molecules under mild conditions. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors seeking efficient synthetic pathways.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the nitration of sensitive substrates in active pharmaceutical ingredient (API) development.
• Agrochemical Manufacturing: Used in the synthesis of nitro-containing herbicides, fungicides, and insecticides.
• Energetic Materials Research: Employed in the controlled nitration of organic compounds for specialty explosives and propellants.
• Polymer & Material Science: Facilitates surface modification and the creation of nitro-functionalized polymers and silicones.
• Organic Synthesis & Catalysis: Acts as a silylating agent to protect hydroxyl groups and as a nitration reagent in complex multi-step reactions.
• Laboratory Reagent: Used in analytical chemistry and academic research for specific derivatization and functionalization reactions.

Basic Information

Product Name	Nitric Acid Trimethylsilyl Ester
CAS No.	18026-82-9
Molecular Formula	C3H9NO3Si
Molecular Weight	135.19 g/mol
Synonyms	Trimethylsilyl Nitrate; Nitric Acid Trimethylsilyl Ester; TMS Nitrate; Trimethylsilyl Nitrate (TMSONO2); (Nitrato-O)trimethylsilane; Silicon Nitrate Trimethyl Ester; O-Trimethylsilyl Nitrate; Nitric Acid O-Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our Nitric Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at temperatures between 2°C and 8°C. Due to its highly volatile and easily oxidized nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) and handle in a controlled environment to minimize decomposition and moisture exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (GC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.