Description

1-(Trimethylsilylethynyl)Cyclohexene is a specialized organosilicon building block featuring a cyclohexene ring and a trimethylsilyl-protected alkyne moiety. This unique structure makes it a valuable intermediate for synthesizing complex organic frameworks, particularly in advanced materials and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, agrochemical, and material science industries. The compound's reactivity allows for selective deprotection and further functionalization, enabling the construction of novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), leveraging its protected alkyne for click chemistry and cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where its silicon group can act as a temporary protecting group or a functional handle.
• Material Science Research: Employed in the development of advanced organic electronic materials, liquid crystals, and polymers, where the cyclohexene and alkyne units contribute to desired physical properties.
• Organic Synthesis Building Block: A versatile reagent for constructing complex natural products and specialty chemicals via Sonogashira coupling, hydrosilylation, and other metal-catalyzed transformations.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions to form carbon-carbon bonds, essential for creating complex molecular structures in a controlled manner.
• Protecting Group Strategy: The trimethylsilyl group protects the terminal alkyne during multi-step syntheses, which can be selectively removed under mild conditions to reveal the reactive alkyne.

Basic Information

Product Name	1-(Trimethylsilylethynyl)Cyclohexene
CAS No.	17988-44-2
Molecular Formula	C11H18Si
Molecular Weight	178.35 g/mol
Synonyms	Cyclohexene, 1-[(trimethylsilyl)ethynyl]-; 1-Ethynyl-1-cyclohexene, trimethylsilyl derivative; (1-Cyclohexen-1-ylethynyl)trimethylsilane; Trimethyl((1-cyclohexen-1-yl)ethynyl)silane; 1-(Trimethylsilylethynyl)-1-cyclohexene; 1-Cyclohexen-1-yl(trimethylsilyl)acetylene; TMS-Protected 1-Ethynylcyclohexene
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilylethynyl)Cyclohexene is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, NMR, and HPLC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We are committed to meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.