Description

Trimethylsilylbenzenesulfonate is a versatile organosilicon reagent primarily used as a powerful silylating agent and protecting group activator. Its value lies in its ability to introduce the trimethylsilyl (TMS) group under mild conditions, facilitating critical transformations in complex synthetic pathways. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for process development and scale-up.

Application

• Pharmaceutical Synthesis: Key intermediate and protecting group reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for nucleosides and sensitive drug molecules.
• Agrochemical Manufacturing: Used in the production of advanced pesticides and herbicides where selective silylation is required.
• Polymer & Material Science: Acts as a surface modifier and cross-linking agent in the development of specialty silicones and high-performance polymers.
• Organic Synthesis: Employed as a catalyst or co-reagent in various condensation, esterification, and sulfonation reactions.
• Analytical Chemistry: Utilized as a derivatization agent in gas chromatography (GC) and mass spectrometry (MS) to improve the volatility and detection of analytes.
• Fine Chemical Production: Serves as a building block for synthesizing more complex organosilicon compounds and specialty chemicals.

Basic Information

Product Name	Trimethylsilylbenzenesulfonate
CAS No.	17882-06-3
Molecular Formula	C9H14O3SSi
Molecular Weight	230.36 g/mol
Synonyms	Benzenesulfonic Acid Trimethylsilyl Ester; Trimethylsilyl Benzenesulfonate; Phenyl Trimethylsilyl Sulfonate; TMS Benzenesulfonate; (Trimethylsilyloxy)benzenesulfonic Acid; Trimethylsilyl Phenylsulfonate; TMSOSO2Ph
EINECS	Contact for details

Quality Control

Our Trimethylsilylbenzenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.