Description

2-Pyridinecarboxylicacid,Trimethylsilylester(9Ci) is a versatile organosilicon-protected derivative of picolinic acid, serving as a key synthetic intermediate and protecting group reagent. Its primary value lies in enabling complex organic synthesis, particularly in pharmaceutical and agrochemical research, by offering a stable, silylated form of the reactive carboxylic acid moiety. This compound is essential for R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors who require high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing pyridine or nicotinic acid derivatives.
• Agrochemical Synthesis: Serves as a key building block for creating novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Employed in the development of novel metal-organic complexes and catalysts for asymmetric synthesis.
• Peptide Mimetics & Bio-conjugation: Acts as a protected carboxylic acid handle for constructing peptide analogs and bioconjugates.
• Material Science Precursor: Utilized in the synthesis of functionalized polymers and organic electronic materials.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis and medicinal chemistry.

Basic Information

Product Name	2-Pyridinecarboxylicacid,Trimethylsilylester(9Ci)
CAS No.	17881-49-1
Molecular Formula	C9H13NO2Si
Molecular Weight	195.29 g/mol
Synonyms	Picolinic Acid Trimethylsilyl Ester; Trimethylsilyl Picolinate; 2-(Trimethylsilyloxycarbonyl)pyridine; Picolinic Acid TMS Ester; 2-Pyridinecarboxylic Acid Trimethylsilyl Ester; TMS Picolinate; Nicotinic Acid Trimethylsilyl Ester (isomer); 2-Carboxypyridine Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our production of 2-Pyridinecarboxylicacid,Trimethylsilylester(9Ci) adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical B2B applications. Each lot undergoes comprehensive analysis including identification, purity assay, and impurity profiling via modern analytical techniques. Certificates of Analysis (COA) detailing all specifications are provided with every shipment, and we support customer audits and quality agreements to meet the exacting standards of the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.