Description

Bis-Trimethylsilylacetamide (CAS NO 17879-45-7) is a highly reactive organosilicon reagent primarily used as a powerful silylating agent. It is essential for protecting sensitive functional groups, such as hydroxyls and amines, during complex synthetic sequences in research and manufacturing. This compound is a critical raw material for pharmaceutical intermediates, agrochemicals, and advanced material science, valued for its efficiency in derivatization and analysis.

Application

• Pharmaceutical Synthesis: Key reagent for protecting hydroxyl and amino groups in the production of active pharmaceutical ingredients (APIs) and complex intermediates.
• Gas Chromatography (GC) Derivatization: Used to silylate polar compounds (e.g., sugars, acids, steroids) to improve their volatility and thermal stability for accurate analysis.
• Agrochemical Manufacturing: Employed in the synthesis of silicon-containing pesticides and herbicides where silylation is a crucial step.
• Polymer & Material Science: Acts as a modifier or cross-linking agent in the development of silicone-based polymers and specialty materials.
• Peptide & Carbohydrate Chemistry: Facilitates the protection of functional groups during the synthesis of sensitive biomolecules.
• Analytical Chemistry: Utilized as a derivatization agent in HPLC and MS sample preparation to enhance detection of analytes.

Basic Information

Product Name	Bis-Trimethylsilylacetamide
CAS No.	17879-45-7
Molecular Formula	C8H21NOSi2
Molecular Weight	203.43 g/mol
Synonyms	BSA; N,O-Bis(trimethylsilyl)acetamide; Acetamide, N,N-bis(trimethylsilyl)-; Bistrimethylsilylacetamide; BSA (silylating agent); N,O-Bis(trimethylsilyl)acetamide; TMSA; 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine, N-acetyl derivative
EINECS	241-848-1

Quality Control

Our Bis-Trimethylsilylacetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by GC or titration and impurity profiling, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its highly volatile and hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.417 - 1.421
Density (20°C)	0.83 - 0.87 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.