Description

Trimethylsilyl p-Toluenesulphonate is a versatile organosilicon reagent primarily used as a powerful silylating agent and protecting group activator. This compound matters for its ability to introduce the trimethylsilyl (TMS) group under mild conditions, facilitating critical transformations in complex organic syntheses. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for API development and specialty chemical production.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent in the protection and deprotection of hydroxyl groups during the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the production of advanced pesticides and herbicides where selective silylation is required.
• Peptide Chemistry: Employed as a coupling agent or for protecting group manipulation in solid-phase and solution-phase peptide synthesis.
• Nucleoside & Carbohydrate Chemistry: Facilitates the selective silylation of sugar hydroxyl groups in the synthesis of nucleoside analogs and complex carbohydrates.
• Polymer Science: Acts as a modifier or initiator in the synthesis of specialized silicone-based polymers and functional materials.
• Analytical Derivatization: Used to prepare volatile derivatives of polar compounds for Gas Chromatography (GC) and Mass Spectrometry (MS) analysis.
• Fine Chemical Production: Serves as a catalyst or promoter in various esterification and etherification reactions for high-value specialty chemicals.
• Research & Development: A staple reagent in organic chemistry R&D labs for method development and exploring new synthetic pathways.

Basic Information

Product Name	Trimethylsilyl p-Toluenesulphonate
CAS No.	17872-98-9
Molecular Formula	C10H16O3SSi
Molecular Weight	244.38 g/mol
Synonyms	Trimethylsilyl p-Toluenesulfonate; Trimethylsilyl Tosylate; TMSOTf (common abbreviation); p-Toluenesulfonic Acid Trimethylsilyl Ester; Trimethylsilyl 4-Methylbenzenesulfonate; TMS Tosylate; Tosyloxytrimethylsilane; 4-Methylbenzenesulfonic Acid Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our Trimethylsilyl p-Toluenesulphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (HPLC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.