Description

2-Trimethylsilyloxy-3-Butyne is a specialized organosilicon reagent featuring a protected alkynol functionality. This compound is valued for its role as a versatile synthetic building block in advanced organic synthesis, enabling the controlled introduction of the 3-butyn-2-ol moiety under mild conditions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediates: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing acetylene or propargylic alcohol substructures.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that require tailored alkynyl components.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and silicon-containing hybrid materials.
• Organic Synthesis Reagent: Employed in Sonogashira couplings, click chemistry, and other metal-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Protecting Group Strategy: The trimethylsilyloxy group acts as a protective group for the hydroxyl function, allowing selective reactions elsewhere on the molecule.
• Ligand and Catalyst Development: Useful in the preparation of novel ligands for asymmetric catalysis and organometallic complexes.

Basic Information

Product Name	2-Trimethylsilyloxy-3-Butyne
CAS No.	17869-76-0
Molecular Formula	C7H14OSi
Molecular Weight	142.27 g/mol
Synonyms	3-Butyn-2-ol, 2-(trimethylsilyl)-; 2-(Trimethylsilyl)-3-butyn-2-ol; 3-Butyn-2-ol trimethylsilyl ether; Trimethyl(3-butyn-2-yloxy)silane; 2-Trimethylsiloxy-3-butyne; TMS-Protected 3-Butyn-2-ol; O-Trimethylsilyl-3-butyn-2-ol
EINECS	Contact for details

Quality Control

Our 2-Trimethylsilyloxy-3-Butyne is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including GC, NMR, and FT-IR to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee it meets the stringent requirements for research and industrial synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed when not in use and away from heat, sparks, and open flames. Incompatible with strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.