Description

Phalloidin is a potent bicyclic heptapeptide mycotoxin, a key biochemical tool for selectively and irreversibly binding to filamentous actin (F-actin). This compound matters for its critical role in stabilizing actin filaments, preventing their depolymerization, which is essential for advanced cytoskeleton research and diagnostics. It is primarily needed by researchers and manufacturers in the fields of cell biology, pharmacology, and biomedical diagnostics, where precise visualization and quantification of the actin cytoskeleton are required.

Application

• Fluorescent Staining in Cell Biology: Conjugated to fluorophores (e.g., FITC, TRITC, Alexa Fluor® dyes) for high-resolution visualization of F-actin in fixed cells and tissues.
• Cytoskeleton Stabilization Studies: Used in biochemical assays to stabilize actin filaments for in vitro polymerization and binding studies.
• Pharmacological Research: Employed as a toxin model to study hepatotoxicity and the mechanisms of cell death, particularly in liver cells.
• Diagnostic Assay Development: Serves as a critical component in diagnostic kits for detecting actin in pathological samples.
• Neuroscience Research: Applied in studies of neuronal structure and growth cone dynamics where the actin cytoskeleton plays a pivotal role.
• High-Content Screening (HCS): Utilized in automated imaging platforms for drug discovery campaigns targeting the cytoskeleton.

Basic Information

Product Name	Phalloidin
CAS No.	17466-45-4
Molecular Formula	C35H48N8O11S
Molecular Weight	788.87 g/mol
Synonyms	Phalloidine; Toxin Phalloidin; Phalloidin from *Amanita phalloides*; (3S,6S,9S,12R,15S,18S,21S,24S,33S,36S)-15-(2-Amino-2-oxoethyl)-33-[(1R)-1-hydroxyethyl]-3,6,9,12,18,21,24,30,33,36-decamethyl-1,4,7,10,13,16,19,22,25,28,31,34-dodecaoxo-1-thia-4,7,10,13,16,19,22,25,28,31,34-undecaazacyclohexatriacontane-36-carboxylic acid
EINECS	241-456-1

Quality Control

Our Phalloidin is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for life science research. Certificates of Analysis (COA) detailing purity, potency, and analytical methods are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Conforms (F-actin binding assay)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.