Description

Picropodophyllotoxin is a potent and specific inhibitor of the insulin-like growth factor-1 receptor (IGF-1R), derived from the natural lignan podophyllotoxin. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for oncology and metabolic disease studies. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors who are developing targeted cancer therapies and investigating IGF-1R signaling pathways.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel anti-cancer agents and targeted therapeutics.
• Biochemical Research: Used as a highly specific IGF-1R inhibitor to study cell proliferation, apoptosis, and signal transduction mechanisms in cancer biology.
• Reference Standard: Employed as an analytical standard in quality control (QC) and research laboratories for method development, validation, and compound identification via HPLC, LC-MS, or NMR.
• Preclinical Drug Development: Utilized in in vitro and in vivo studies to evaluate the efficacy and mechanism of action of potential IGF-1R-targeting drugs.
• Academic Research: A vital tool for universities and research institutes exploring tyrosine kinase inhibitors and their role in various disease models.

Basic Information

Product Name	Picropodophyllotoxin
CAS No.	17434-18-3
Molecular Formula	C22H22O8
Molecular Weight	414.41 g/mol
Synonyms	PPP; AXL1717; (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; IGF-1R Inhibitor; Cyclolignan PPP; Picropodophyllin; NSC 39580
EINECS	Contact for details

Quality Control

Our Picropodophyllotoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.