Description

(2R)-2-Hydroxy-3-Methylbutyric Acid is a chiral hydroxy acid of significant interest in fine chemical synthesis. This compound matters as a versatile chiral building block and intermediate for producing high-value pharmaceuticals, agrochemicals, and flavor/fragrance ingredients. It is needed by R&D chemists and process development teams in the pharmaceutical, nutraceutical, and specialty chemical industries seeking to introduce stereochemistry into their target molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting metabolic and neurological pathways.
• Agrochemical Synthesis: Building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy and environmental profile.
• Flavor and Fragrance Industry: Used in the production of natural-identical flavor compounds and aroma chemicals, contributing to complex sensory profiles.
• Biocatalyst and Enzyme Studies: Serves as a substrate or inhibitor in enzymatic reactions and biochemical research.
• Asymmetric Synthesis: Employed as a chiral auxiliary or resolving agent in stereoselective chemical transformations.
• Nutraceutical and Cosmetic Ingredients: Intermediate for synthesizing bioactive compounds and specialty esters used in personal care formulations.

Basic Information

Product Name	(2R)-2-Hydroxy-3-Methylbutyric Acid
CAS No.	17407-56-6
Molecular Formula	C5H10O3
Molecular Weight	118.13 g/mol
Synonyms	(R)-2-Hydroxy-3-methylbutanoic Acid; D-2-Hydroxy-3-methylbutyric Acid; (R)-3-Methyl-2-hydroxybutyric Acid; (2R)-2-Hydroxy-3-methylbutanoic Acid; (R)-α-Hydroxy-β-methylbutyric Acid; L-Valine metabolite; (R)-HMB precursor
EINECS	Contact for details

Quality Control

Our (2R)-2-Hydroxy-3-Methylbutyric Acid is produced under strict quality management systems. We offer material suitable for research and commercial scale applications, with typical purity grades exceeding 98% (by HPLC). Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and specific impurities are provided with each batch to ensure compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.