Description

Pyridine, 4-Amino-3-(Trimethylsilyl)- (8Ci) is a specialized organosilicon derivative of aminopyridine, characterized by the presence of a reactive amino group and a protective trimethylsilyl moiety. This unique structure makes it a valuable versatile building block and key intermediate in advanced organic synthesis, particularly for the development of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, where it facilitates the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, especially those requiring silyl-protected amine functionalities.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the pyridine core and silyl group offer specific bioactivity and stability.
• Ligand and Catalyst Development: Acts as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling and other catalytic reactions.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for advanced materials, such as organic semiconductors or metal-organic frameworks (MOFs).
• Organic Synthesis Building Block: Utilized in multi-step syntheses to introduce both amino and silyl protecting groups, enabling complex molecular architectures.
• Chemical Research & Development: A key reagent for academic and industrial research exploring new reaction methodologies involving silicon-nitrogen chemistry.

Basic Information

Product Name	Pyridine, 4-Amino-3-(Trimethylsilyl)- (8Ci)
CAS No.	17379-44-1
Molecular Formula	C8H14N2Si
Molecular Weight	166.30 g/mol
Synonyms	3-(Trimethylsilyl)-4-aminopyridine; 4-Amino-3-(trimethylsilyl)pyridine; 4-Pyridinamine, 3-(trimethylsilyl)-; 3-Trimethylsilyl-4-aminopyridine; 4-Amino-3-trimethylsilylpyridine; 4-ATMP; TMS-4-APy; (3-Pyridinyl)-4-amine, 3-(trimethylsilyl)-
EINECS	Contact for details

Quality Control

Our production of Pyridine, 4-Amino-3-(Trimethylsilyl)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes rigorous analytical testing, including HPLC and NMR analysis, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.