Description

3-(Trimethylsilyl)Pyridine-4-Carbonitrile is a versatile organosilicon building block featuring a pyridine core functionalized with both a nitrile and a trimethylsilyl group. This unique structure makes it a critical intermediate for synthesizing complex molecules in advanced research and development. It is particularly valuable for pharmaceutical chemists and agrochemical researchers seeking to introduce silicon-containing moieties or utilize the nitrile group for further derivatization.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders or as protease inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the silyl group can influence bioavailability and metabolic stability.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands in coordination chemistry and catalysis, particularly in cross-coupling reactions.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, or metal-organic frameworks (MOFs) due to its conjugated system and functional handles.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological processes, leveraging the nitrile group for click chemistry or other bioconjugation strategies.

Basic Information

Product Name	3-(Trimethylsilyl)Pyridine-4-Carbonitrile
CAS No.	17379-38-3
Molecular Formula	C9H12N2Si
Molecular Weight	176.30 g/mol
Synonyms	4-Cyano-3-(trimethylsilyl)pyridine; 3-Trimethylsilyl-4-cyanopyridine; 4-Pyridinecarbonitrile, 3-(trimethylsilyl)-; Pyridine-4-carbonitrile, 3-(trimethylsilyl)-; TMS-Pyridine-4-CN
EINECS	Contact for details

Quality Control

Our 3-(Trimethylsilyl)Pyridine-4-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.