Description

2-Amino-2-Methyl-Propionic Acid Ethyl Ester Hydrochloride is a high-purity organic salt derivative of a non-proteinogenic amino acid, valued for its role as a key protected intermediate in advanced organic synthesis. Its primary commercial importance lies in enabling the controlled introduction of the sterically hindered 2-aminoisobutyric acid (Aib) moiety, which is critical for modifying peptide backbone conformation and stability. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical sectors, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of peptidomimetics and active pharmaceutical ingredients (APIs), particularly those incorporating the Aib residue to enhance metabolic stability and conformational rigidity.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected amino acid ester for creating peptides with modified properties for research and therapeutic applications.
• Agrochemical Research: Serves as an intermediate in the development of novel herbicides, fungicides, and plant growth regulators that utilize amino acid analogs.
• Specialty Polymer Chemistry: Acts as a monomer or chain modifier for synthesizing specialized polyamides and other polymers with unique thermal and mechanical characteristics.
• Bioconjugation & Linker Chemistry: Utilized in the preparation of chemical linkers and for bioconjugation strategies in drug delivery system development and diagnostic agent formulation.
• Chemical Biology Research: Employed as a tool compound to study protein structure-function relationships and to create non-natural amino acid analogs for probing biological systems.

Basic Information

Product Name	2-Amino-2-Methyl-Propionic Acid Ethyl Ester Hydrochloride
CAS No.	17288-15-2
Molecular Formula	C6H14ClNO2
Molecular Weight	167.63 g/mol
Synonyms	Ethyl 2-Amino-2-methylpropionate Hydrochloride; 2-Amino-isobutyric acid ethyl ester hydrochloride; Aib-OEt·HCl; Ethyl 2-aminoisobutyrate hydrochloride; 2-Methylalanine ethyl ester hydrochloride; Ethyl α-aminoisobutyrate hydrochloride; L-A-2-Methylalanine ethyl ester hydrochloride; Ethyl 2-amino-2-methylpropanoate hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Amino-2-Methyl-Propionic Acid Ethyl Ester Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details
Solubility	Freely soluble in water, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.