Description

4-Carboxybenzenesulfonyl Azide is a versatile sulfonyl azide derivative, a key reagent in click chemistry and polymer modification processes. Its primary value lies in its ability to act as a highly efficient coupling agent for introducing sulfonyl azide functional groups, enabling precise chemical transformations under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for applications in bioconjugation, cross-linking, and the synthesis of novel polymers and small molecule libraries.

Application

• Click Chemistry Reagent: Used in copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions for bioconjugation and labeling.
• Polymer Functionalization: A critical agent for post-polymerization modification, introducing reactive sites or cross-linking points into polymer backbones to tailor material properties.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, especially those requiring sulfonamide or triazole linkages.
• Surface Modification: Employed to functionalize material surfaces (e.g., nanoparticles, chips, membranes) with azide groups for subsequent bio-immobilization or property enhancement.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the sulfonyl azide moiety is integral to the bioactive structure.
• Cross-linking Agent: Applied in the creation of hydrogels, elastomers, and other cross-linked networks for biomedical and industrial applications.
• Proteomics Research: Utilized in chemical proteomics for activity-based protein profiling (ABPP) and identifying enzyme active sites.
• Material Science Research: A foundational reagent for developing new functional materials, including self-healing polymers and smart coatings.

Basic Information

Product Name	4-Carboxybenzenesulfonyl Azide
CAS No.	17202-49-2
Molecular Formula	C7H5N3O4S
Molecular Weight	227.20 g/mol
Synonyms	4-Azidosulfonylbenzoic Acid; p-Carboxybenzenesulfonyl Azide; Benzoic acid, 4-(azidosulfonyl)-; 4-(Azidosulfonyl)benzoic Acid; Terephthalic Acid Sulfonyl Azide; p-Azidosulfonylbenzoic Acid; 4-Sulfonylazidobenzoic Acid; Azidocarbonylbenzenesulfonic Acid (related form)
EINECS	Contact for details

Quality Control

Our 4-Carboxybenzenesulfonyl Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.