Description

L-4-Nitrophenylalanine Methyl Ester Hydrochloride is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of 4-nitro-L-phenylalanine. This compound serves as a crucial chiral building block and intermediate in sophisticated organic synthesis, offering a reactive handle for peptide coupling and further functionalization. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, protease inhibitors, and other bioactive molecules where the nitro group can be selectively reduced or transformed.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and enzyme inhibitors.
• Protease Inhibitor Synthesis: Used in constructing active site-directed inhibitors for various proteolytic enzymes.
• Peptide Chemistry: Serves as a protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology Probes: Incorporated into peptides used as activity-based probes or substrates for studying enzyme mechanisms.
• Asymmetric Synthesis: Utilized as a starting material for the synthesis of non-natural amino acids and complex chiral molecules.
• Academic & Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	L-4-Nitrophenylalanine Methyl Ester Hydrochloride
CAS No.	17193-40-7
Molecular Formula	C10H12N2O4 • HCl
Molecular Weight	260.67 (Free base) / 297.13 (HCl salt)
Synonyms	L-p-Nitrophenylalanine Methyl Ester Hydrochloride; (S)-Methyl 2-amino-3-(4-nitrophenyl)propanoate hydrochloride; Methyl L-4-nitrophenylalaninate hydrochloride; 4-Nitro-L-phenylalanine methyl ester HCl; H-Phe(4-NO2)-OMe • HCl; Fmoc-Phe(4-Nitro)-OH methyl ester precursor; 4-Nitrophenylalanine methyl ester hydrochloride (L-form)
EINECS	Contact for details

Quality Control

Our L-4-Nitrophenylalanine Methyl Ester Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and chiral integrity is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.