Description

Estra-1,3,5(10)-Triene-3,16,17-Triol, Tris(Hydrogen Sulfate), (16Alpha ,17Beta)- is a high-purity, sulfated derivative of estriol, a naturally occurring estrogen. This compound is critical for pharmaceutical research and development, particularly in the study of hormone metabolism, targeted drug delivery, and the synthesis of novel steroid conjugates. It serves as a key advanced intermediate for researchers and manufacturers in the steroid and pharmaceutical industries who require precise, well-characterized molecules for their processes.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel estrogen-based therapeutics and prodrugs.
• Biochemical Research: Used in studies of estrogen sulfation pathways, enzyme kinetics (sulfotransferases), and hormone receptor interactions.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in steroid analysis.
• Prodrug Development: The sulfate groups can be utilized for designing water-soluble prodrugs with modified bioavailability profiles.
• Metabolite Studies: Essential for investigating the metabolic fate of estriol and related steroid hormones in vitro and in vivo.

Basic Information

Item	Details
Product Name	Estra-1,3,5(10)-Triene-3,16,17-Triol, Tris(Hydrogen Sulfate), (16Alpha ,17Beta)-
CAS No.	17181-21-4
Molecular Formula	C18H24O12S3
Molecular Weight	528.56 g/mol
Synonyms	Estriol Trisulfate; Estriol 3,16,17-Trisulfate; 16α,17β-Estriol 3,16,17-Trisulfate; E3S3; NSC 121773; Trisodium Estriol 3-Sulfate 16,17-Disulfate (salt form); 3,16,17-Trihydroxyestra-1,3,5(10)-trien-3-yl trisulfate
EINECS	Contact for details

Quality Control

Every batch of our Estra-1,3,5(10)-Triene-3,16,17-Triol, Tris(Hydrogen Sulfate) is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) including HPLC purity, spectral identification (IR, NMR), and related substance profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.