Description

(S)-(-)-2-Isocyanatoglutaric Acid Diethyl Ester is a high-value, chiral isocyanate derivative of glutamic acid, serving as a critical building block for the synthesis of complex, stereochemically defined molecules. Its primary value lies in enabling the efficient, asymmetric construction of pharmacologically active compounds, particularly through the formation of urea or carbamate linkages. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries who require enantiomerically pure intermediates for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors, enzyme modulators, and other active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Peptidomimetic Synthesis: Used to incorporate non-natural, constrained amino acid analogs into peptide chains to enhance stability, bioavailability, and biological activity.
• Agrochemical Research: Building block for creating novel, enantiomerically pure herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Modification: Employed to introduce reactive isocyanate groups into polymer backbones for creating specialty polyurethanes or functionalized materials with tailored properties.
• Chemical Biology Probes: Useful for labeling or cross-linking biomolecules to study protein interactions and enzyme mechanisms.

Basic Information

Product Name	(S)-(-)-2-Isocyanatoglutaric Acid Diethyl Ester
CAS No.	17046-23-0
Molecular Formula	C₁₀H₁₅NO₅
Molecular Weight	229.23 g/mol
Synonyms	(S)-2-Isocyanatopentanedioic Acid Diethyl Ester; Diethyl (S)-2-Isocyanatoglutarate; L-2-Isocyanatoglutaric Acid Diethyl Ester; (S)-Diethyl 2-Isocyanatoglutarate; (2S)-2-Isocyanatopentanedioic Acid Diethyl Ester; Glutaric acid, 2-isocyanato-, diethyl ester, (S)-; NSC 334365
EINECS	Contact for details

Quality Control

Our (S)-(-)-2-Isocyanatoglutaric Acid Diethyl Ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including chiral HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and potentially light-sensitive nature. Keep away from heat, open flames, and incompatible materials such as water, alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.