Description

n-(Trifluoroacetyl)-L-Isoleucine 1-Methylpropyl Ester is a high-purity, chiral protected amino acid derivative essential for advanced organic synthesis. This compound is a critical building block in the production of complex peptides and active pharmaceutical ingredients (APIs), offering precise stereochemical control. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics and conducting sophisticated chemical research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and complex bioactive molecules.
• Peptide Chemistry: Used for the introduction and protection of the L-isoleucine moiety during solid-phase and solution-phase peptide synthesis (SPPS).
• Proteomics Research: Serves as a specialty reagent in biochemical research for studying protein structure, function, and enzyme-substrate interactions.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct molecules with high enantiomeric purity.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Fine Chemical Production: Acts as a precursor in the manufacture of specialized agrochemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Isoleucine 1-Methylpropyl Ester
CAS No.	16974-97-3
Molecular Formula	C11H18F3NO3
Molecular Weight	269.26 g/mol
Synonyms	L-Isoleucine, N-[(trifluoroacetyl)-, 1-methylpropyl ester; N-(Trifluoroacetyl)-L-isoleucine sec-butyl ester; (2S,3S)-2-[(Trifluoroacetyl)amino]-3-methylpentanoic acid 1-methylpropyl ester; N-TFA-L-isoleucine sec-butyl ester; (2S,3S)-2-[(Trifluoroacetamido)]-3-methylpentanoic acid sec-butyl ester; sec-Butyl N-(trifluoroacetyl)-L-isoleucinate; N-α-(Trifluoroacetyl)-L-isoleucine 1-methylpropyl ester
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Isoleucine 1-Methylpropyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with high-purity standards for research and pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.