Description

n-(Trifluoroacetyl)-L-Leucine 1-Methylpropyl Ester is a high-purity, protected amino acid derivative used as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing the L-leucine side chain with a trifluoroacetyl-protected amine, enabling precise control in peptide and pharmaceutical intermediate manufacturing. It is primarily required by research institutions and industrial-scale producers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate a protected L-leucine residue.
• Proteomics Research: Serves as a reagent in biochemical research for studying protein structure and function.
• Chemical Biology: Employed in the development of enzyme inhibitors, receptor ligands, and other bioactive molecules.
• Fine Chemical Production: Acts as a precursor for more complex, high-value specialty chemicals and catalysts.
• Agrochemical Synthesis: Utilized in the research and development of advanced, chiral agrochemicals.

Basic Information

Product Name	n-(Trifluoroacetyl)-L-Leucine 1-Methylpropyl Ester
CAS No.	16974-96-2
Molecular Formula	C12H20F3NO3
Molecular Weight	283.29 g/mol
Synonyms	L-Leucine, N-[(trifluoroacetyl)-, 1-methylpropyl ester; N-(Trifluoroacetyl)-L-leucine sec-butyl ester; (S)-2-((2-Methylbutoxy)carbonylamino)-4-methyl-1,1,1-trifluoropentan-3-one; N-TFA-L-leucine sec-butyl ester; sec-Butyl N-(trifluoroacetyl)-L-leucinate; 1-Methylpropyl N-(trifluoroacetyl)-L-leucinate; N-[(Trifluoroacetyl)-L-leucine] sec-butyl ester
EINECS	Contact for details

Quality Control

Our n-(Trifluoroacetyl)-L-Leucine 1-Methylpropyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.