Description

Boc-Glu(Ome)-Onp CAS NO 16947-07-2 is a protected amino acid derivative, specifically the p-nitrophenyl ester of N-tert-butoxycarbonyl-L-glutamic acid α-methyl ester. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled, sequential addition of glutamic acid residues. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioconjugates for therapeutic and diagnostic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): Key reagent for the efficient incorporation of glutamic acid with orthogonal side-chain protection.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Preparation of peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.
• Chemical Biology: Tool for introducing glutamic acid motifs into probes and biomaterials to study protein function and interactions.
• Process Development: Used in the scale-up and optimization of peptide manufacturing processes under GMP conditions.

Basic Information

Product Name	Boc-Glu(Ome)-Onp
CAS No.	16947-07-2
Molecular Formula	C₁₇H₂₂N₂O₈
Molecular Weight	382.37 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-glutamic acid 1-methyl ester 5-(4-nitrophenyl) ester; Boc-L-glutamic acid α-methyl ester γ-p-nitrophenyl ester; Boc-Glu(OMe)-ONp; (S)-5-((tert-Butoxycarbonyl)amino)-4-methoxy-5-oxopentanoic acid 4-nitrophenyl ester; N-Boc-L-glutamic acid α-methyl ester γ-4-nitrophenyl ester; Nα-Boc-L-glutamic acid 1-methyl ester 5-(4-nitrophenyl) ester; Boc-Glu-OMe-ONp; Boc-Glu(OMe)-ONp ester
EINECS	Contact for details

Quality Control

Our Boc-Glu(Ome)-Onp is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer-specific requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.