Description

Trimethylsilyl Isobutyrate is a versatile organosilicon reagent featuring a reactive silyl ester group. This compound is valued for its role as a silylating agent and a protected form of isobutyric acid in sophisticated organic synthesis. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active ingredients and advanced intermediates.

Application

• Silylating Agent: Used to introduce the trimethylsilyl (TMS) protecting group onto hydroxyl, carboxyl, or other labile functional groups in multi-step synthetic routes.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug molecules, particularly where acid-sensitive protecting groups are required.
• Agrochemical Synthesis: Employed in the production of advanced pesticide and herbicide intermediates that require silicon incorporation or protection strategies.
• Polymer & Material Science: Acts as a modifier or cross-linking agent in the development of silicone-based polymers and advanced materials.
• Flavor & Fragrance Ingredient Synthesis: Used in the preparation of esters and other compounds where the isobutyrate moiety is desired under mild conditions.
• Laboratory Reagent: A valuable tool in research laboratories for derivatization in analytical chemistry and exploratory organic synthesis.

Basic Information

Product Name	Trimethylsilyl Isobutyrate
CAS No.	16883-61-7
Molecular Formula	C7H16O2Si
Molecular Weight	160.29 g/mol
Synonyms	Isobutyric Acid Trimethylsilyl Ester; Trimethylsilyl 2-Methylpropanoate; TMS-Isobutyrate; (CH3)3SiOCOCH(CH3)2; 2-Methylpropanoic Acid Trimethylsilyl Ester; Trimethylsilyl Ester of Isobutyric Acid; NSC 163083
EINECS	240-921-9

Quality Control

Our Trimethylsilyl Isobutyrate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat and ignition sources. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.