Description

L-Isoleucine-tert-Butyl Ester Dibenzene is a protected amino acid derivative, specifically the tert-butyl ester of L-isoleucine. This compound is a crucial chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, offering enhanced stability and solubility for specific reaction pathways. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for advanced organic synthesis and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs, protease inhibitors, and other bioactive molecules.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) where the tert-butyl ester protecting group is required.
• Bioconjugation: Serves as a precursor for creating modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugation strategies.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to induce chirality.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.
• Fine Chemical Production: Used in the custom synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.

Basic Information

Product Name	L-Isoleucine-tert-Butyl Ester Dibenzene
CAS No.	16874-08-1
Molecular Formula	C16H25NO2
Molecular Weight	263.38 g/mol
Synonyms	L-Isoleucine tert-Butyl Ester; (2S,3S)-2-Amino-3-methylpentanoic acid tert-butyl ester; tert-Butyl L-isoleucinate; L-Ile-OtBu; Boc-Ile-OtBu (when referring to N-Boc protected form); (S,S)-Isoleucine tert-butyl ester; Isoleucine, tert-butyl ester, L-; 2-Amino-3-methylpentanoic acid, 1,1-dimethylethyl ester, (2S,3S)-
EINECS	Contact for details

Quality Control

Our L-Isoleucine-tert-Butyl Ester Dibenzene is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for pharmaceutical R&D and synthesis. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment to guarantee supply reliability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.