Description

Trimethylsilyl Propionate is a versatile organosilicon compound widely used as a derivatization agent and protecting group in synthetic chemistry. Its primary value lies in its ability to silylate reactive functional groups, enhancing the volatility and stability of target molecules for analytical and process applications. This product is essential for manufacturers and R&D laboratories in the pharmaceutical, agrochemical, and specialty chemical sectors seeking reliable, high-purity intermediates.

Application

• Gas Chromatography (GC) Derivatization: Used to silylate carboxylic acids, alcohols, and other polar compounds to improve their thermal stability and detection sensitivity.
• Pharmaceutical Synthesis: Serves as a key protecting group for hydroxyl and carboxyl functionalities during multi-step synthesis of active pharmaceutical ingredients (APIs).
• Polymer & Resin Modification: Acts as a surface modifier or cross-linking agent to alter the hydrophobicity and chemical resistance of polymers.
• Analytical Sample Preparation: Employed in mass spectrometry (MS) and other analytical techniques to derivative samples for accurate quantification.
• Agrochemical Intermediate: Utilized in the synthesis of certain herbicides and pesticides where silicon incorporation is beneficial.
• Silicone Chemistry: Functions as a precursor or intermediate in the production of specialized silicone oils and elastomers.

Basic Information

Product Name	Trimethylsilyl Propionate
CAS No.	16844-98-7
Molecular Formula	C6H14O2Si
Molecular Weight	146.26 g/mol
Synonyms	Propanoic Acid, 2-(Trimethylsilyl)-; 2-(Trimethylsilyl)propanoic Acid; 2-Trimethylsilylpropionic Acid; TMS-Propionate; TMSP; TSP; 3-(Trimethylsilyl)propionic Acid (common misnomer); DSS-d6 (Deuterated analog used as NMR reference)
EINECS	240-865-1

Quality Control

Our Trimethylsilyl Propionate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and titration, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your application requirements. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Ensure containers are tightly sealed after use to prevent evaporation and potential moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.410 - 1.415
Density (20°C)	0.88 - 0.92 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.